MOTS-C in Australia

Mitochondrial-derived peptide encoded in the 12S rRNA gene. MOTS-c is a 16-amino-acid peptide encoded inside the mitochondrial genome rather than the nuclear genome, one of a small family of mitochondrial-derived peptides discovered in the 2010s. It acts as a signal from mitochondria to the rest of the cell and is studied for metabolic regulation and exercise physiology.

AMPK activation: folate-cycle inhibition and energy sensing. Insulin sensitivity: glucose disposal in obese rodents. Exercise physiology: endurance and muscle adaptation. Ageing research: age-dependent decline in circulating levels. Lee et al. (Cell Metab 2015) reported that MOTS-c prevented diet-induced obesity and insulin resistance in mice. Reynolds et al. (Nat Commun 2021) showed it improved physical performance in young, middle-aged and old mice. Human data are observational, showing exercise-induced increases.

Mice on a high-fat diet given MOTS-c did not develop obesity or insulin resistance; aged mice improved physical performance; circulating MOTS-c rises after exercise in humans. No human intervention trial has reported.

No human safety data. Rodent studies reported no toxicity at the doses used.

Published MOTS-C studies specify their own amounts and routes, and those vary by model and endpoint. Peptide Aus products are supplied for in-vitro laboratory research, so we do not provide dosing, cycle or usage guidance for people. For laboratory preparation, the reconstitution calculator converts vial size and water volume into concentration and syringe units.

Both are studied for metabolic flexibility; MOTS-c through AMPK, 5-Amino-1MQ through NNMT.

SS-31 protects mitochondrial membranes; MOTS-c is a mitochondrial signal to the nucleus.

Humanin is another mitochondrial-derived peptide, studied for cell survival rather than metabolism.

The 10mg vial covers assay development; 20mg and 40mg reduce cost per milligram for extended rodent or cell protocols.

With bacteriostatic water added slowly down the inside wall of the vial, then swirled gently. Each vial size lists its suggested volume, and the calculator converts volume to concentration.

Lyophilised: −20 °C, sealed, away from light and moisture. Reconstituted: 2–8 °C, used within 8–12 weeks, never frozen.

MOTS-C is not registered by the Therapeutic Goods Administration (TGA) as a medicine in Australia and is not approved for human or veterinary use. Peptide Aus supplies it as a research reagent for in-vitro laboratory work only. Supply of any substance for human use in Australia is governed by the Poisons Standard and the Therapeutic Goods Act, and the buyer is responsible for using the material lawfully. If you are looking for a treatment, speak to a doctor.

Directly from Peptide Aus, from Australian stock, in 3 vial sizes from $94.99 (10mg) to $159.99 (40mg). Prices are AUD and GST inclusive. Paid orders before 2pm AEST/AEDT dispatch the same business day, tracked.