SLU-PP-332 (5mg)

Pan-ERR (oestrogen-related receptor) agonist. SLU-PP-332 is a synthetic small molecule that activates all three oestrogen-related receptors (ERRα, β and γ), nuclear receptors that coordinate the gene programs muscle switches on during endurance exercise. Developed at Saint Louis University, it is studied as an 'exercise mimetic' in preclinical models.

Mitochondrial biogenesis: pGC-1α and ERR target genes in muscle. Endurance capacity: treadmill performance in mouse models. Energy expenditure: indirect calorimetry in obese rodents. Fibre-type shift: oxidative fibre markers in skeletal muscle. Billon et al. (ACS Pharmacol Transl Sci 2023) reported improved endurance and mitochondrial gene expression; a follow-up in diet-induced obese mice reported reduced fat gain with increased energy expenditure. All published data are preclinical.

Mice given SLU-PP-332 ran roughly 50–70% longer in treadmill tests and showed increased oxidative muscle fibres; obese mice gained less fat with higher energy expenditure. All data are preclinical.

No human data exist. Rodent studies reported no overt toxicity over the short study periods; effects of sustained ERR activation on heart and other tissues are not characterised.

Published SLU-PP-332 studies specify their own amounts and routes, and those vary by model and endpoint. Peptide Aus products are supplied for in-vitro laboratory research, so we do not provide dosing, cycle or usage guidance for people. For laboratory preparation, the reconstitution calculator converts vial size and water volume into concentration and syringe units.

SLU-PP-332 is a small molecule that was given by injection in the published rodent work; oral activity is discussed but not established. Peptide Aus supplies it as a powder for reconstitution for laboratory use.

Both are small molecules rather than peptides; SLU-PP-332 targets exercise-response genes, 5-Amino-1MQ targets NNMT.

Both are studied as exercise-related metabolic signals; MOTS-c is an endogenous peptide, SLU-PP-332 a synthetic receptor agonist.

Add about 1 mL of bacteriostatic water slowly down the inside of the vial and swirl gently; do not shake. 5mg in 1 mL gives 5 mg/mL. Refrigerate at 2–8 °C after reconstitution and use within 8–12 weeks. The calculator has this vial preset.

Lyophilised: −20 °C, sealed, away from light and moisture. Reconstituted: 2–8 °C, used within 8–12 weeks, never frozen.

SLU-PP-332 is not registered by the Therapeutic Goods Administration (TGA) as a medicine in Australia and is not approved for human or veterinary use. Peptide Aus supplies it as a research reagent for in-vitro laboratory work only. Supply of any substance for human use in Australia is governed by the Poisons Standard and the Therapeutic Goods Act, and the buyer is responsible for using the material lawfully. If you are looking for a treatment, speak to a doctor.

Directly from Peptide Aus, from Australian stock: SLU-PP-332 (5mg) is $105.99 AUD including GST. Paid orders before 2pm AEST/AEDT dispatch the same business day, tracked.